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nerve impulse arrives at axon terminal of motor neuron and triggers release of acetylcholine
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step 1
nerve impulse arrives at axon terminal of motor neuron and triggers release of acetylcholine
step 2
ach diffuses across synaptic cleft, binds to its receptors in the motor end plate and triggers a muscle action potential (AP).
step 3
acetylcholinesterase in synaptic cleft destroys ach so another muscle action potential does not arise unless more ach is relaeased from motor neuron.
step 4
muscle action potential travelling along transverse tubule opens ca release channels in the sarcoplasmic reticulum (SR) membrane which allows calcium ions to flood into sarcoplasm.
step 5
ca binds to troponin on the thin filament, exposing the binding sites for myosin.
step 6
contraction: power strokes use atp; myosin heads bind to actin, swivel, and release; thin filaments are pulled toward center of sarcomere.
step 7
ca release channels in sarcoplasmic reticulum close and ca active transport pumps use atp to restore low levels of ca in sarcoplasm.
step 8
troponin-tropomyosin complex slides back into position where it blocks the myosin binding sites on actin.
step 9
muscle relaxes.
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